Adlyxin
MED-000011
Adlyxin® (lixisenatide) is a once-daily, mealtime GLP-1 receptor agonist approved as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes. Unlike weekly GLP-1 medications, Adlyxin is timed to a meal and taken once daily within the hour before the first meal of the day.
Medication Overview
Generic Name:
Medication Class:
Manufacturer:
Route:
Dosing Frequency:
Lixisenatide
GLP-1
Sanofi
Injection
Daily
Status:
Draft
Medication Summary
Adlyxin® (lixisenatide) is a once-daily, mealtime GLP-1 receptor agonist approved as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes. Unlike weekly GLP-1 medications, Adlyxin is timed to a meal and taken once daily within the hour before the first meal of the day.
Aliases
Adlyxin
Search Keywords
adlyxin, lixisenatide
Medication Uses
Part of the DietApp.com GLP-1 Medication Database, a comprehensive, regularly reviewed reference covering every GLP-1-class medication.
Adlyxin® (lixisenatide) is an FDA-approved GLP-1 receptor agonist indicated as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes. It's a once-daily, mealtime-timed injection — a different dosing pattern from the once-weekly GLP-1 medications like Ozempic or Trulicity.
Adlyxin is not approved for type 1 diabetes or diabetic ketoacidosis, and should not be used as a substitute for insulin.
Dosage
The starting dose of Adlyxin is 10 mcg subcutaneously once daily for 14 days. The dose is then increased to the maintenance dose of 20 mcg once daily starting on day 15.
Administration
Adlyxin is injected within the hour before the first meal of the day, ideally the same meal each day. It's administered subcutaneously into the abdomen, thigh, or upper arm.
Benefits
When used as prescribed, Adlyxin may help lower blood sugar levels in adults with type 2 diabetes, particularly by targeting post-meal blood sugar spikes given its mealtime dosing pattern.
Side Effects
The most frequently reported side effects include nausea (up to 26.5% of patients), vomiting (up to 10.5%), headache, diarrhea, dizziness, and hypoglycemia — particularly when combined with a sulfonylurea or insulin. In clinical trials, about 70% of patients developed antibodies to lixisenatide; a small subset with the highest antibody levels showed reduced blood sugar benefit.
Warnings
Adlyxin carries warnings for anaphylaxis and serious hypersensitivity reactions (reported in about 0.1% of patients in trials), pancreatitis, and increased hypoglycemia risk when combined with insulin or a sulfonylurea. Never share an Adlyxin pen between patients, even with a new needle. Seek immediate medical attention for severe abdominal pain, difficulty breathing, or facial/throat swelling.
Drug Interactions
Adlyxin slows gastric emptying, which may reduce or delay the absorption of oral medications taken around the same time — including antibiotics, acetaminophen, and oral contraceptives. Oral contraceptives should be taken at least 1 hour before or at least 11 hours after an Adlyxin dose. When combined with a sulfonylurea or basal insulin, a dose reduction of that medication may be needed to reduce hypoglycemia risk.
Storage
Before first use, refrigerate Adlyxin pens at 36°F–46°F (2°C–8°C). Do not freeze. Follow manufacturer instructions for in-use storage. Keep out of reach of children.
References
- U.S. FDA prescribing information for Adlyxin®
- DailyMed prescribing information
- RxList: Adlyxin Side Effects and Dosing
Last medically reviewed and updated: July 11, 2026.
Track Your Progress
Because Adlyxin is timed to a specific meal each day, tracking when you inject alongside your food log can help you and your provider see how well your dose timing is working. DietApp.com helps you log daily doses, meals, blood sugar patterns, and side effects in one place.
Related Resources
- Semaglutide Medication Guide
- Trulicity Medication Guide
- GLP-1 Medication Library
- Type 2 Diabetes Management Resources
- Medication Safety Information
Related Articles
- What Is Lixisenatide?
- Mealtime vs. Weekly GLP-1 Medications: What's the Difference?
- How GLP-1 Medications Support Blood Sugar Control
- Frequently Asked Questions About GLP-1 Therapy
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